Abstract #5074

Repeatability and Reproducibility of Diffusion Tensor MRI and 2-Point Dixon Fat Fraction Measurements in the Muscle

Matthew Farrow^1,2, Ai Lyn Tan^1,2, Maya Buch^1,2, Paul Emery^1,2, Andrew Grainger², Steven Tanner², and John Biglands²

¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

Muscle deterioration is associated with fat infiltration and alterations in muscle fibre architecture. Quantitative MRI measurements may be able to detect subtle muscle changes. However, before these can be considered for research and clinical use, the repeatability and reproducibility of these measurements must be established. 19 healthy participants had two scans separated by 30 minutes and diffusion and fat fraction measurements were obtained in the thigh. Test-retest repeatability, intra-rater repeatability and inter-rater reproducibility were assessed. Both diffusion and fat fraction measurements showed excellent repeatability and reproducibility suggesting that these measurements may be sufficiently precise to allow the study of subtle changes in muscle.

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