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Abstract #5076

Muscle specific role of acetylcarnitine concentration and IMCL accumulation as a marker for long term glycemic control: 3T 1H MRS study

Radka Klepochová1,2, Magdalena Bastian3, Michael Krebs3, Siegfried Trattnig1,2, Alexandra Kautzky-Willer3, and Martin Krššák1,2,3

1High-Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

Acetylcarnitine can be observed non-invasively in 1H MRspectra in skeletal muscle and its inverse relationship to intramyocellular lipids and metabolic markers of chronic hyperglycemia was suggested. This study aimed to compare the acetylcarnitine concentrations and intramyocellular lipids content in tibialis anterior and soleus of four different groups of volunteers with broad range of glycemic control by 1HMRS on 3Tscanner. Differences in the patient phenotype were mirrored by increased intramyocellular lipids in the tibialis anterior and decreased acetylcarnitine in soleus of type2diabetes patients. This muscle specific behavior of intramyocellular metabolites could represent different fiber composition in examined muscles.

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