Abstract #5078

Intravoxel Inchoerent Motion MRI to Evaluate Post-Occlusive Reactive Hyperemia in Calf Muscles

Alfonso Mastropietro¹, Simone Porcelli¹, Marcello Cadioli^2,3, Letizia Rasica^1,4, Elisa Scalco¹, Simonetta Gerevini³, Mauro Marzorati¹, and Giovanna Rizzo¹

¹Institute of Bioimaging and Molecular Physiology, Consiglio Nazionale delle Ricerche, Segrate, Italy, ²Philips Healthcare, Monza, Italy, ³Department of Neuroradiology, Ospedale San Raffaele, Milano, Italy, ⁴Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milano, Italy

The main goal of this study was to evaluate changes of IVIM parameters related to muscle perfusion changes occurring in the calf of healthy subjects before, during and after transitory ischemia of lower limb. MRI acquisitions were performed on 11 healthy volunteers on a 3T scanner. IVIM was performed on the right calf before, during and after arterial occlusion. A slight redcution of D* and fD* was observed during ischemia whereas a significant increase of D*, fD* and D was observed during hyperemia. IVIM appears as a promising tool to evaluate muscle perfusion related parameters in ischemia/hyperemia.

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