Abstract #5083

In vivo Current Density and Conductivity Tensor Imaging of Human Brain During TACS using DT-MREIT

Munish Chauhan¹, Aprinda Indahlastari², Aditya Kumar Kasinadhuni³, Christopher Saar¹, Bakir Mousa¹, Kevin Castellano⁴, Thomas H Mareci⁴, and Rosalind J Sadleir¹

¹SBHSE, Arizona State University, Tempe, AZ, United States, ²Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States, ³GE Healthcare, Wausau, WI, United States, ⁴Dept. of Biochemistry & Molecular Biology, University of Florida, Gainesville, FL, United States

Knowledge of the electrical properties of brain tissue is key to developing better understanding of whole brain function. In this study, we present the first in vivo images of anisotropic conductivity distribution in the human head, measured at a frequency of ~10 Hz. We used MREIT techniques to encode phase changes caused by transcranial AC current flow (TACS) within the head via two independent electrode pairs. These results were then combined with DTI data to reconstruct full anisotropic conductivity distributions in 5 mm-thick slices of the brains of two participants. Conductivity values recovered in the study were broadly consistent with literature values.

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