Curcumin has been used for the treatment of inflammatory diseases in oriental medicine, and its anti-inflammatory effect was recently reported. In this feasibility study, hepato-protective effect of curcumin was imaged in rat liver cirrhosis model, which was induced with dimethylnitrosamine (DMN). Magnetic resonance (MR)-based electrical conductivity imaging method was applied to evaluate tissue condition associated with protective effect. From electrical conductivity images, damaged liver tissues by DMN showed decreased conductivity than normal liver tissues. In contrast, cirrhotic tissues with curcumin treatment showed increased conductivity which was similar to normal tissue.
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