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Abstract #5100

In Vitro Imaging of Therapeutic Effect of Curcumin on Liver Cirrhosis using MR-based Electrical Conductivity Imaging Method

Bup Kyung Choi1, Nitish Katoch1, In Ok Ko2, Ji Ae Park2, Jin Woong Kim3, Hyung Joong Kim1, Oh In Kwon4, and Eung Je Woo1

1Biomedical Engineering, Kyung Hee University, Seoul, Republic of Korea, 2Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea, 3Radiology, Chonnam National University Medical School, Gwangju, Republic of Korea, 4Konkuk University, Seoul, Republic of Korea

Curcumin has been used for the treatment of inflammatory diseases in oriental medicine, and its anti-inflammatory effect was recently reported. In this feasibility study, hepato-protective effect of curcumin was imaged in rat liver cirrhosis model, which was induced with dimethylnitrosamine (DMN). Magnetic resonance (MR)-based electrical conductivity imaging method was applied to evaluate tissue condition associated with protective effect. From electrical conductivity images, damaged liver tissues by DMN showed decreased conductivity than normal liver tissues. In contrast, cirrhotic tissues with curcumin treatment showed increased conductivity which was similar to normal tissue.

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