Abstract #5100

In Vitro Imaging of Therapeutic Effect of Curcumin on Liver Cirrhosis using MR-based Electrical Conductivity Imaging Method

Bup Kyung Choi¹, Nitish Katoch¹, In Ok Ko², Ji Ae Park², Jin Woong Kim³, Hyung Joong Kim¹, Oh In Kwon⁴, and Eung Je Woo¹

¹Biomedical Engineering, Kyung Hee University, Seoul, Republic of Korea, ²Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea, ³Radiology, Chonnam National University Medical School, Gwangju, Republic of Korea, ⁴Konkuk University, Seoul, Republic of Korea

Curcumin has been used for the treatment of inflammatory diseases in oriental medicine, and its anti-inflammatory effect was recently reported. In this feasibility study, hepato-protective effect of curcumin was imaged in rat liver cirrhosis model, which was induced with dimethylnitrosamine (DMN). Magnetic resonance (MR)-based electrical conductivity imaging method was applied to evaluate tissue condition associated with protective effect. From electrical conductivity images, damaged liver tissues by DMN showed decreased conductivity than normal liver tissues. In contrast, cirrhotic tissues with curcumin treatment showed increased conductivity which was similar to normal tissue.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.