Abstract #5104

Mapping the Brain’s water content and low-frequency electrical properties through T1-weighted MRI imaging

Cornelia Wenger¹, Catherine Tempel-Brami², Hadas Sara Hershkovich², Moshe Giladi², and Zeev Bomzon²

¹Novocure GmbH, Root, Switzerland, ²Novocure, Haifa, Israel

This study investigates the possibility to extend the water-content based electrical properties tomography (wEPT) technique to lower frequencies. The wEPT approach assumes that electrical properties (EP) of brain tissues can be estimated from water-content (WC) which is derived from two T1-weighted MRIs. Adapted wEPT model parameters were evaluated from ex-vivo measurements of calf brain tissue samples. We performed wEPT estimations in an in-vivo rat brain tumor model, followed by ex-vivo measurements of brain extracted samples. Results predict good correlation between WC ex-vivo measurements and in-vivo wEPT estimations. Yet, mapping EPs with wEPT at lower frequencies needs further investigation.

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