Abstract #5110

Phase-locked CEST – Introducing dynamic B0-correction to gagCEST

Johannes Windschuh¹, Moritz Zaiss², Jae-Seung Lee^1,3, Alexej Jerschow³, and Ravinder Regatte¹

¹Center of Biomedical Imaging, New York University Langone Health, New York, NY, United States, ²Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Thuebingen, Germany, ³Department of Chemistry, New York University, New York, NY, United States

Even a small frequency drift of less than 1Hz/min of the MRI scanner can have a strong impact on gagCEST measurements. We propose a dynamic B₀-correction that tracks the frequency shift using the phase images provided by the GRE readout. We show that this correction eliminates the influence of the frequency drift on gagCEST without the need of additional measurement time allowing higher accuracy, reproducibility, and comparability of gagCEST studies.

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