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Abstract #5113

Accelerating 3D CEST Imaging with Low Rank Sparse Reconstruction

Huajun She1, Ece Ercan1, Shu Zhang1, Xinzeng Wang1, Jochen Keupp2, Anath Madhuranthakam1,3, Ivan Dimitrov1,4, Robert Lenkinski1,3, and Elena Vinogradov1,3

1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Philips Research, Hamburg, Germany, 3Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 4Philips Healthcare, Gainesville, FL, United States

Chemical exchange saturation transfer (CEST) is a new contrast mechanism in MRI. However, a successful application of CEST is hampered by its slow acquisition especially in the 3D applications. Compressed sensing (CS) is powerful for reconstruction of highly undersampled data. This work implements the 3D pulsed steady-state CEST acquisition sequence and extended the low rank plus sparse (L+S) method to a 3D version. The phantom and in vivo human brain results demonstrate our design has the potential to accelerate the 3D CEST imaging about 4 times.

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