Salicylate analogues feature chemical shift far from water (Δω = 8-10 ppm), however, there are almost no available reports on their in vivo detection of salicylate upon intravenous administration. We aim to optimize the in vivo detection of NaSA, by comparing compared MTRasym and a Dynamic Salicylate Enhancement (DSE). For the mice brain with LPS-induced inflammation, there are ~4% DSE signal which displays a clear kinetic trend. While MTRasm values are very small, oscillating between -2% to 0% due to the unsymetric MTC. In conclusion, our DSE method is able to track the dynamic signal changes following the infusion of NaSA.