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Abstract #5134

3D Fiber Aligned Strain Rate: Application to Unilateral Limb Suspension Induced Atrophy

Usha Sinha1, Vadim Malis2, and Shantanu Sinha3

1Physics, San Diego State University, San Diego, CA, United States, 2Physics, UC San Diego, La Jolla, CA, United States, 3Radiology, UC San Diego, San Diego, CA, United States

2D and 3D strain rate imaging has been recently introduced to study local tissue deformations. The strain rate tensors are represented in the principal basis while further relevant physiological information can be obtained by extracting 3D strain rate tensors in the muscle fiber basis; the latter is determined by diffusion tensor imaging. Here, we present the methodological developments to extract 3D fiber aligned strain rate images and application to study atrophy induced by Unilateral limb suspension. FASR indices were much smaller than those extracted in the principle basis and further studies are required to understand FASR changes with suspension.

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