Abstract #5136

Reproducibility of calf-muscle perfusion measurements from dynamic contrast-enhanced MRI

Christopher C Conlin¹, Jiawei Dong¹, Stephen Decker², Nan Hu³, Mariya A Chadovich¹, Michelle T Mueller⁴, Lillian L Khor⁵, Christopher J Hanrahan¹, Gwenael Layec², Vivian S Lee¹, and Jeff L Zhang¹

¹Department of Radiology and Imaging Sciences, University of Utah School of Medicine, Salt Lake City, UT, United States, ²Division of Geriatrics, University of Utah School of Medicine, Salt Lake City, UT, United States, ³Division of Biostatistics, University of Utah School of Medicine, Salt Lake City, UT, United States, ⁴Division of Vascular Surgery, University of Utah School of Medicine, Salt Lake City, UT, United States, ⁵Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States

This study examined the reproducibility of calf-muscle perfusion measurements from DCE-MRI following plantar-flexion exercise, which is a promising technique for assessing calf-muscle function and viability. In a group of healthy subjects, the same post-exercise DCE-MRI protocol was repeated on two different days and calf-muscle perfusion measurements were compared between the two visits. High correlation and agreement of perfusion between visits was observed for the posterior calf muscles, demonstrating that a plantar-flexion exercise protocol followed by DCE-MRI is suitable for achieving precise measurements of calf-muscle perfusion.

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