Meeting Banner
Abstract #5138

The interplay of MRS measured skeletal muscle acetylcarnitine, mitochondrial function and glucose availability

Anne Tonson1, Robert W Wiseman1,2, Ronald A Meyer1, Taylor Ann Callahan2, Ashley Lang2, and Jill M Slade2

1Physiology, Michigan State University, East Lansing, MI, United States, 2Radiology, Michigan State University, East Lansing, MI, United States

Recently resting muscle acetylcarnitine content (AC) has been proposed as a marker for peripheral insulin resistance. However, muscle oxidative capacity and glucose availability may largely contribute to interindividual AC fluctuations independent of peripheral insulin sensitivity. In this study we monitored resting muscle AC in healthy subjects using 1H MRS in response to carbohydrate ingestion and examined the relationship of fasting muscle AC to muscle oxidative capacity measured by 31P MRS. Our results show a strong relationship between mitochondrial capacity and fasting muscle AC and also show that carbohydrate ingestion causes a rapid sharp decline in muscle AC.

This abstract and the presentation materials are available to members only; a login is required.

Join Here