Abstract #5155

Ultra-short echo time (UTE) imaging with Three-component fitting analysis of human cortical bone

Xing Lu^1,2, Saeed Jerban¹, Michael Carl³, Wenhui Yang², Annette von Drygalski⁴, Eric Y Chang⁵, and Jiang Du¹

¹Department of Radiology, University of California, San Diego, San Diego, CA, United States, ²Institute of Electrical Engineering, Chinese Academy of Science, Beijing, China, ³GE Healthcare, San Diego, CA, United States, ⁴Department of Medicine, Division of Hematology/Oncology, University of California, San Diego, San Diego, CA, United States, ⁵Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Increased cortical porosity is a major cause of the decreased strength of osteoporotic bone, which can be evaluated by MRI based bone water components analysis. The chemical shift caused by fat in the bone may lead to incorrect estimation of water components with a bi-component exponential model. Thus, we propose a tri-component fitting method for accurate bound and pore water quantification incorporating a multi-peak spectral modeling of fat. Nine human cortical bone samples were studied. Our results suggest improved curve fitting and additional information when a tri-component analyses is used.

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