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Abstract #5157

Time interleaved multi-gradient-echo imaging with UTE and non-UTE sampling for simultaneous PDFF, T2* and magnetic susceptibility mapping of cortical bone

Sophia Kronthaler1, Maximilian Nikolaus Diefenbach1, Stefan Ruschke1, Jakob Meineke2, Holger Eggers2, Peter Boernert2, and Dimitrios Karampinos1

1Department of Diagnostic and Interventional Radiology, TUM Klinikum rechts der Isar, Munich, Germany, 2Philips Research Laboratory, Hamburg, Germany

Recently, quantitative magnetic susceptibility mapping (QSM) is gaining attention in the context of probing bone microstructure with potential clinical application in the assessment of bone health. Particularly, in bone applications the presence of multiple chemical species including short and long T2* components embedded in the bone environment poses several challenges including rapid signal decay, fieldmap estimation and chemical species separation. Using non-UTE QSM leads to signal voids in cortical bone regions complicating QSM. Therefore, the present study investigates the application of a stack-of-stars time-interleaved multi-gradient echo sequence including UTE and regular echo sampling for bone QSM.

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