Meeting Banner
Abstract #5159

Correlation study between micro-architecture of trabecular bone and magnetic resonance transverse relaxation times at multiple spatial resolutions

DongKyu Lee1, Youngkyu Song2, Bumwoo Park1, Hwapyung Cho1, Gyunggoo Cho2, and HyungJoon Cho1

1Bio-Medial Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea, 2Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Republic of Korea

The effects of magnetic resonance (MR) imaging resolutions on the correlations between standard trabecular structural indices and MR transverse relaxation-times (T2 and T2*) were evaluated by performing Monte Carlo proton diffusion simulations, ex vivo experiments with defatted human trabecular specimens, and bovine knee trabecular samples with intact bone marrow via 7T system. T2 relaxation-time robustly represented the trabecular micro-architecture, such as trabecular spacing and number, while T2* was vulnerable with degrading spatial resolution. T2 relaxation times may facilitate the radiation-free diagnosis to assess osteoporotic fractures and therapy response for deep trabecular areas within a feasible scan time on a 7T system.

This abstract and the presentation materials are available to members only; a login is required.

Join Here