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Abstract #5209

Improved fibre tracking with optimized diffusion-weighted single-refocused spin echo EPI

Manoj Shrestha1, Pavel Hok1,2, Ulrike Nöth1, Bianca Lienerth1, and Ralf Deichmann1

1Brain Imaging Center (BIC), Goethe University Frankfurt, Frankfurt am Main, Germany, 2Department of Neurology, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic

This study investigates the suitability of data acquired with an optimized diffusion-weighted (DW) single-refocused spin-echo EPI sequence for fibre tracking. The proposed scheme uses dummy scans of 1.5s duration prior to the acquisition of each multi-slice data volume, thus driving eddy-currents into a steady-state, thus allowing to use an optimized parameter setting of the eddy-current correction tool “EDDY”. Results show that the proposed sequence yields better fibre tracking results than conventional DW sequences with a more precise estimation of the subsidiary fibre orientations, showing additional connections to the lateral frontal, parietal and temporal cortices and to the thalamus.

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