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Abstract #5211

Personalized Lesion Profiling in Multiple Sclerosis

Sidong Liu1,2, Alexander Klistorner1,2,3, Chenyu Wang1,4, Yang Gao5, Brittany Gilchrist2,3, Yang Song6, Yuyi You2, Junen Yao5, Weidong Cai6, and Michael Barnett1,4

1Brain and Mind Centre, University of Sydney, Sydney, Australia, 2Save Sight Institute, University of Sydney, Sydney, Australia, 3Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia, 4Sydney Neuroimaging Analysis Centre, Sydney, Australia, 5School of Instrumentation Science and Opto-Electronics Engineering, Beihang University, Beijing, China, 6School of Information Technologies, University of Sydney, Sydney, Australia

The pathology of multiple sclerosis (MS) lesions is highly subject-specific, therefore personalized lesion analysis is important in assessing the degree of disease-related brain damage and the patient’s response to therapy. Separating and comparing lesional and non-lesional tissue provides an “internal control” and, therefore, increased precision of measurement of the degree of lesional damage in the brain. Here we present a novel and fully automatic method to create a personalized lesion profile of the subject based on DTI tractography, which can be used to assess whole brain lesional damage. This technique can be applied to measure microstructural change using any MRI modality, and may have high translational impact in clinical trials and neurological research.

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