Abstract #5220

Automated fibre tractography of the optic radiation for epilepsy surgery planning

Sjoerd B Vos^1,2,3, Matteo Mancini^1,3, Vejay Vakharia^3,4, Rachel Sparks^1,3, Mei Iok Chiang^1,5, M Jorge Cardoso¹, John S Duncan^2,3,4, Gavin P Winston^2,4,6, and Sebastien Ourselin^1,3,4,7

¹Translational Imaging Group, University College London, London, United Kingdom, ²MRI Unit, Epilepsy Society, Chalfont St Peter, United Kingdom, ³Wellcome EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London, London, United Kingdom, ⁴Department of Clinical and Experimental Epilepsy, University College London, London, United Kingdom, ⁵Center for Disease Control and Prevention, Health Bureau, Macau, Macau, ⁶Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Canada, ⁷Dementia Research Centre, University College London, London, United Kingdom

Fibre tractography of the optic radiation can be helpful in epilepsy surgery, but its widespread clinical use is hampered by the need for time-consuming expert manual ROI delineations and interrater variability. Our automated approach using anatomically constrained geodesic shape-based averaging is evaluated on two diffusion MRI datasets from different scanners. Automatically generated tracts are within the interrater agreement of two expert raters when evaluating for distance between temporal pole and Meyer’s loop for both datasets, with a tendency towards a more inclusive Meyer’s loop in the automated method.

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