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Abstract #5220

Automated fibre tractography of the optic radiation for epilepsy surgery planning

Sjoerd B Vos1,2,3, Matteo Mancini1,3, Vejay Vakharia3,4, Rachel Sparks1,3, Mei Iok Chiang1,5, M Jorge Cardoso1, John S Duncan2,3,4, Gavin P Winston2,4,6, and Sebastien Ourselin1,3,4,7

1Translational Imaging Group, University College London, London, United Kingdom, 2MRI Unit, Epilepsy Society, Chalfont St Peter, United Kingdom, 3Wellcome EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London, London, United Kingdom, 4Department of Clinical and Experimental Epilepsy, University College London, London, United Kingdom, 5Center for Disease Control and Prevention, Health Bureau, Macau, Macau, 6Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Canada, 7Dementia Research Centre, University College London, London, United Kingdom

Fibre tractography of the optic radiation can be helpful in epilepsy surgery, but its widespread clinical use is hampered by the need for time-consuming expert manual ROI delineations and interrater variability. Our automated approach using anatomically constrained geodesic shape-based averaging is evaluated on two diffusion MRI datasets from different scanners. Automatically generated tracts are within the interrater agreement of two expert raters when evaluating for distance between temporal pole and Meyer’s loop for both datasets, with a tendency towards a more inclusive Meyer’s loop in the automated method.

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