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Abstract #5223

Accurate fibre dispersions from varying the b-tensor shape

Michiel Cottaar1, Filip Szczepankiewicz2,3, Matteo Bastiani1, Stamatios N. Sotiropoulos1,4, Markus Nilsson2, and Saad Jbabdi1

1Wellcome Centre for Integrative Neuroscience (WIN) - FMRIB, University of Oxford, Oxford, United Kingdom, 2Clinical Sciences Lund, Department of Radiology, Lund University, Lund, Sweden, 3Random Walk Imaging AB, Lund, Sweden, 4Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom

Accurate measures of fibre dispersion might improve tractography through voxels with bending and/or fanning configurations and also provide more accurate tissue microstructure indices. When estimated from regular diffusion MRI, however, the accuracy of the dispersion estimate depends on the accuracy of the underlying microstructural model. In this work, we find that encoding water diffusion using multiple shapes of the b-tensor leads to an accurate measurement of fibre dispersion within a single b-shell. We show that this holds for complicated sub-voxel geometries using both simulations and in vivo data.

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