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Abstract #5235

Estimating axon diameter distributions beyond the physical limits of acquisition capabilities

Mark Drakesmith1, Suryanarayana Umesh Rudrapatna1, Silvia de Santis1, and Derek K Jones1

1CUBRIC, Cardiff University, Cardiff, United Kingdom

Estimation of axon diameter distributions (ADDs) is hindered by the fact that axon diameters below a certain limit, which are prevalent throughout the nervous system, are invisible to a diffusion MRI protocol. Here we propose a simple modification to the AxCaliber protocol where only the portions of the ADD that can feasibly generate a signal are modelled, by fitting to a truncated distribution. We show in simulations and human data acquired on a high-gradient (300mT/m) system that using this approach produces ADD estimates much closer to those observed in histology.

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