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Abstract #5239

Diffusion Weighting with Linear and Planar Encoding Solves Degeneracy in Parameter Estimation

Bibek Dhital1, Marco Reisert1, Elias Kellner1, and Valerij G. Kiselev1

1Clinic for Radiology, Medical Physics, Faculty of Medicine, Medical Center - University of Freiburg, Germany, Freiburg, Germany

While estimating parameters of tissue microstructure models has never been simple, the recently discovered bi-modality (degeneration) of objective function in parameter space render it highly challenging. This study proposes a response to this challenge based on combining the commonly used linear encoding (the b-matrix with the diagonal 0,0,b) with the planar encoding (b,b,0). The signal was simulated in the whole parameter space of the standard model of brain white matter. Exhaustive search in this space demonstrates the absence of bi-modality when results for both encoding schemes are treated together.

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