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Abstract #5242

Isotropic Diffusometry MRI of the human brain

Alexandru V Avram1, Joelle E Sarlls2, and Peter J Basser3

1NIBIB, National Institutes of Health, Bethesda, MD, United States, 2NINDS, National Institutes of Health, Bethesda, MD, United States, 3NICHD, National Institutes of Health, Bethesda, MD, United States

From diffusion MRI data acquired with isotropic diffusion encoding over a wide range of b-values, we estimate intravoxel distributions of mean diffusivities using a regularized Inverse Laplace Transform analysis. In vivo spectra of intra-voxel mean diffusivities measured in healthy subjects show consistent single-peak distributions in most brain regions, with subtle differences between white matter, cortical gray matter, subcortical gray matter, corpus callosum, and cerebrospinal fluid. This non-invasive, model-free, whole-brain approach to quantifying spectra of intrinsic tissue water mobilities could improve the clinical diagnosis and characterization of stroke, cancer, and other diseases.

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