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Abstract #5245

Assessing feasibility and reproducibility of a bundle-specific framework on in vivo axon diameter estimates at 300mT/m

Muhamed Barakovic1,2, Gabriel Girard1, David Romascano1, Jonathan Rafael-Patino1, Maxime Descoteaux3,4, Giorgio Innocenti1,5,6, Derek K. Jones2, Jean-Philippe Thiran1,7, and Alessandro Daducci1,7,8

1Signal Processing Laboratory 5 (LTS5), Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland, 2Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom, 3Sherbrooke Connectivity Imaging Laboratory (SCIL), University of Sherbrooke, Sherbrooke, QC, Canada, 4Sherbrooke Molecular Imaging Center, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Science, University of Sherbrooke, Sherbrooke, QC, Canada, 5Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden, 6Brain and Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland, 7University Hospital Center (CHUV) and University of Lausanne, Lausanne, Switzerland, 8Department of Computer Science, University of Verona, Verona, Italy

In vivo quantitative estimation of axon diameter in the white matter is a potential new tool for studying the structural and functional architecture of the brain. Recently, the feasibility of axon diameter estimation with diffusion-weighted MRI (DW-MRI) has been questioned. In this work, we explore the feasibility of bundle-specific axon diameter mapping in the context of a reproducibility study using the Convex Optimization Modeling for Microstructure informed Tractography (COMMIT) framework. Our results show that DW-MRI axon diameter estimatesof the corpus callosum and of the corticospinal tract are comparable to histological reports in previous studies.

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