The lack of a sensitive imaging method capable of capturing the full extent of glioma cell infiltration represents a significant challenge to accurate treatment planning and monitoring of therapeutic response. Here, using a recently developed diffusion MRI method (Linear Multi-Scale Model; LMM), we estimated the changes in restricted, hindered, and free water in six glioma patients pre- and post-treatment. We found scan-to-scan reproducibility of diffusion profiles in normal brain and identified distinct diffusion profiles in the tumor and peritumoral regions at different time points, thus highlighting the robustness of the LMM and its feasibility in the clinical setting.
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