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Abstract #5252

Ultra-High Gradient Diffusion MRI Reveals Distinct Microstructural Changes in Diffuse Gliomas Before and After Radiation Therapy

Ina Ly1, Qiuyun Fan1,2, Barbara Wichtmann3, Aapo Nummenmaa1,2, Ovidiu Andronesi1,2, Brian Nahed1, William Curry1, Daniel Cahill1, Tracy Batchelor1, Jayashree Kalpathy-Cramer1,2, Bruce Rosen1,2, Susie Huang1,2, and Elizabeth Gerstner1

1Massachusetts General Hospital, Boston, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 3Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

The lack of a sensitive imaging method capable of capturing the full extent of glioma cell infiltration represents a significant challenge to accurate treatment planning and monitoring of therapeutic response. Here, using a recently developed diffusion MRI method (Linear Multi-Scale Model; LMM), we estimated the changes in restricted, hindered, and free water in six glioma patients pre- and post-treatment. We found scan-to-scan reproducibility of diffusion profiles in normal brain and identified distinct diffusion profiles in the tumor and peritumoral regions at different time points, thus highlighting the robustness of the LMM and its feasibility in the clinical setting.

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