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Abstract #5263

Combining diffusion and perfusion weighted MRI measurements for disease and treatment monitoring in Multiple Sclerosis

Madalina E Tivarus1, Xing Qiu2, Nicole Zizzi3, and Giovanni Schifitto4

1Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, United States, 2Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, United States, 3University of Rochester, Rochester, NY, United States, 4Department of Neurology, University of Rochester Medical Center, Rochester, NY, United States

In this large sample retrospective study of MS patients with different diagnoses and treatment regimens we investigated interactions between imaging metrics and age, MS phenotype, and types of treatment, and longitudinal changes associated with disease modifying treatments. We assessed WM injury using DTI metrics (FA, MD), and vascular changes (CBF and CBV) using perfusion DSC, in corpus callosum and in its cortical projections. We found significant correlations of perfusion with age, and DTI metrics with disease type and medication, suggesting that advanced neuroimaging methods such as DTI should become integrated into the clinical evaluation of MS patients for improved management.

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