Abstract #5275

MR Microscopy of Cortical Lesions Reveal Iron Loss in Individual Oligodendrocytes

Stephen Dodd¹, Govind Nair², Seung-Kwon Ha³, Daniel Reich³, and Alan Koretsky¹

¹Laboratory of Functional and Molecular Imaging, NINDS, National Institutes of Health, Bethesda, MD, United States, ²Neuroimmunology Clinic, NINDS, National Institutes of Health, Bethesda, MD, United States, ³Translational Neuroradiology Section, NINDS, National Institutes of Health, Bethesda, MD, United States

Imaging of cortical demyelination in chronic multiple sclerosis, has been challenging. Previous MRI studies have detecting signal changes in cortical lesions have been attributed to myelin loss and the presence of iron-laden microglia. Here we demonstrate, in a case study, that MR microscopy may readily identify individual iron-rich cells (primarily oligodendrocytes) and regions. In addition, MR microscopy is shown to allow detailed examination of the central vein signal in white matter lesions.

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