Abstract #5282

Altered Hippocampal GABA and Glutamate Levels and Uncoupling from Functional Connectivity in Multiple Sclerosis

fei gao¹, xuntao yin², weibo chen³, and guangbin wang¹

¹Shandong Medical Imaging Research Institute, Jinan, China, ²Southwest Hospital, Third Military Medical University, chongqing, China, ³Philips Healthcare, shanghai, China

This study offers a novel combination of methods investigating the complex relationships among excitatory/inhibitory neurotransmitters, brain connectivity and cognitive function in health and disease states. Modulation of Glu and GABA neurotransmission may enable the development of new therapeutic strategies for the early stages of MS.

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