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Abstract #5282

Altered Hippocampal GABA and Glutamate Levels and Uncoupling from Functional Connectivity in Multiple Sclerosis

fei gao1, xuntao yin2, weibo chen3, and guangbin wang1

1Shandong Medical Imaging Research Institute, Jinan, China, 2Southwest Hospital, Third Military Medical University, chongqing, China, 3Philips Healthcare, shanghai, China

This study offers a novel combination of methods investigating the complex relationships among excitatory/inhibitory neurotransmitters, brain connectivity and cognitive function in health and disease states. Modulation of Glu and GABA neurotransmission may enable the development of new therapeutic strategies for the early stages of MS.

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