Abstract #5284

Multi-dimensional microstructural imaging offers novel in vivo insights into brain pathology: an application to multiple sclerosis

Kasper Winther Andersen¹, Samo Lasič^1,2, Henrik Lundell¹, Markus Nilsson³, Daniel Topgaard⁴, Filip Szczepankiewicz^2,3, Lars G. Hanson^1,5, Hartwig Roman Siebner^1,6, Morten Blinkenberg⁷, and Tim B. Dyrby^1,8

¹Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, ²Random Walk Imaging, AB, Lund, Sweden, ³Clinical Sciences, Lund, Department of Radiology, Lund University, Lund, Sweden, ⁴Division of Physical Chemistry, Department of Chemistry, Lund University, Lund, Sweden, ⁵Center for Magnetic Resonance, DTU Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark, ⁶Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, ⁷Danish Multiple Sclerosis Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark, ⁸Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kgs. Lyngby, Denmark

Magnetic resonance imaging is today the most versatile imaging method for characterization of multiple sclerosis (MS) in vivo, but clinical examinations lack sensitivity to capture changes in the tissue microstructure. Using a multi-dimensional microstructural imaging approach, we demonstrate how it is possible to obtain more specific and broader microstructural insights about the underlying pathology of MS. For this we use a comprehensive battery of conventional and novel diffusion weighted imaging and quantitative MRI sequences each capable of explaining different and complementary microstructural properties. This allows us to explore the underlying pathology of MS, which is normally only accessible with histology.

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