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Abstract #5284

Multi-dimensional microstructural imaging offers novel in vivo insights into brain pathology: an application to multiple sclerosis

Kasper Winther Andersen1, Samo Lasič1,2, Henrik Lundell1, Markus Nilsson3, Daniel Topgaard4, Filip Szczepankiewicz2,3, Lars G. Hanson1,5, Hartwig Roman Siebner1,6, Morten Blinkenberg7, and Tim B. Dyrby1,8

1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, 2Random Walk Imaging, AB, Lund, Sweden, 3Clinical Sciences, Lund, Department of Radiology, Lund University, Lund, Sweden, 4Division of Physical Chemistry, Department of Chemistry, Lund University, Lund, Sweden, 5Center for Magnetic Resonance, DTU Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark, 6Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, 7Danish Multiple Sclerosis Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark, 8Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kgs. Lyngby, Denmark

Magnetic resonance imaging is today the most versatile imaging method for characterization of multiple sclerosis (MS) in vivo, but clinical examinations lack sensitivity to capture changes in the tissue microstructure. Using a multi-dimensional microstructural imaging approach, we demonstrate how it is possible to obtain more specific and broader microstructural insights about the underlying pathology of MS. For this we use a comprehensive battery of conventional and novel diffusion weighted imaging and quantitative MRI sequences each capable of explaining different and complementary microstructural properties. This allows us to explore the underlying pathology of MS, which is normally only accessible with histology.

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