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Abstract #5318

Functional Connectivity as a Potential Predictor of Treatment Response in  Patients With Major Depressive Disorder

Hailong Li1, Xinyu Hu1, Lianqing Zhang1, Lu Lu1, Xiaoxiao Hu1, Xuan Bu1, Shi Tang1, Qiyong Gong1, and Xiaoqi Huang1

1Huaxi Magnetic Resonance Research Centre (HMRRC) Department of Radiology West China Hospital, Chengdu, China

Resting-state functional connectivity(FC) analyses using a subcallosal cingulate cortex(SCC) seed was applied to major depressive disorder(MDD) patients to characterize a potential neuro-imaging biomarker that identifies the treatment outcome. MDD patients were divided into refractory and non-refractory group according to the treatment response. We found distinguished FC alterations between the three groups especially the lack of FC between SCC and Anterior Cingulate Cortex in the refractory MDD patients. In addition, the alterations in FC correlated with clinical symptoms in different ways in two MDD groups.

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