Water diffusion in tissue is non-Gaussian and the expressions used to calculate diffusion parameters are approximations which introduce systematic errors dependent on the maximum b-value employed. The purpose of this study was to characterize biases in estimates of both apparent diffusion coefficient, and kurtosis and to determine their dependence on maximum b-value. Hence, equations were derived to predict biases in measured diffusion parameters and to explain much of the discrepancy between measurements obtained with different b-values. The equations may also be used to choose appropriate maximum b-values for diffusion-weighted, tensor, and kurtosis imaging.
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