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Abstract #5364

Measurement biases in diffusion and diffusion kurtosis MRI

Nima Gilani1, Hamidreza Saligheh Rad2, and Glyn Johnson3

1Maastricht Brain Imaging Centre (MBIC), Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, 2Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 3Norwich Medical School, University of East Anglia, Norwich, United Kingdom

Water diffusion in tissue is non-Gaussian and the expressions used to calculate diffusion parameters are approximations which introduce systematic errors dependent on the maximum b-value employed. The purpose of this study was to characterize biases in estimates of both apparent diffusion coefficient, and kurtosis and to determine their dependence on maximum b-value. Hence, equations were derived to predict biases in measured diffusion parameters and to explain much of the discrepancy between measurements obtained with different b-values. The equations may also be used to choose appropriate maximum b-values for diffusion-weighted, tensor, and kurtosis imaging.

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