Meeting Banner
Abstract #5381

Demyelination or not: increased radial diffusivity in Parkinson’s disease

Ruimeng Yang1, Pen Sun2, Xiangling Zeng1, Ajit George2, Ajit George2, xinhua Wei1, xinqing jiang1, and Sheng-Kwei Song2

1Guangzhou First People's Hospital, guangzhou, China, 2Washington University School of Medicine, St. Louis, Saint Louis, MO, United States

White matter (WM) integrity alteration has been noted in Parkinson’s disease (PD). Whether the increased radial diffusivity (RD) revealed in previous study using diffusion tensor imaging (DTI) in PD patients is suggestive of demyelinating etiology remains to be established. To further investigate white matter (WM) microstructure changes in PD, diffusion tensor imaging (DTI) and diffusion basis spectrum imaging (DBSI) were analyzed using Tract Based Spatial Statistics (TBSS). Both whole brain voxel-based group analysis and reginal analysis on the corpus callosum were performed. DBSI results suggest that axonal injury is present in PD while no myelin injury was seen.

This abstract and the presentation materials are available to members only; a login is required.

Join Here