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Abstract #5383

Spinal cord axonal diameter variations in the relapsing remitting EAE mouse model of multiple sclerosis

Ahmad Joman Alghamdi1,2, Ian M. Brereton1, Nemat Khan3,4, Maree Smith3,4, and Nyoman D. Kurniawan1

1The Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 2College of Health Sciences, Taif University, Taif, Saudi Arabia, 3Centre for Integrated Preclinical Drug Development, Brisbane, Australia, 4School of pharmacy, The University of Queensland, Brisbane, Australia

This study aimed to determine the extent of axon diameter distribution changes in the lumbar spinal cord in C57BL/6 mice associated with experimental autoimmune encephalomyelitis (EAE). AxCaliber protocol was performed ex-vivo at 16.4T to analyze changes in mice with a range of EAE severity and the effect of treatment with alpha-lipoic acid (R-ALA), a nutraceutical compound that is recently known for suppressing microglial activation and CNS inflammation in EAE rodent models. AxCaliber showed axon diameter increases in mild relapsing remitting EAE group after R-ALA treatment. This might indicate a process of remyelination or other microstructural changes.

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