Abstract #5383

Spinal cord axonal diameter variations in the relapsing remitting EAE mouse model of multiple sclerosis

Ahmad Joman Alghamdi^1,2, Ian M. Brereton¹, Nemat Khan^3,4, Maree Smith^3,4, and Nyoman D. Kurniawan¹

¹The Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ²College of Health Sciences, Taif University, Taif, Saudi Arabia, ³Centre for Integrated Preclinical Drug Development, Brisbane, Australia, ⁴School of pharmacy, The University of Queensland, Brisbane, Australia

This study aimed to determine the extent of axon diameter distribution changes in the lumbar spinal cord in C57BL/6 mice associated with experimental autoimmune encephalomyelitis (EAE). AxCaliber protocol was performed ex-vivo at 16.4T to analyze changes in mice with a range of EAE severity and the effect of treatment with alpha-lipoic acid (R-ALA), a nutraceutical compound that is recently known for suppressing microglial activation and CNS inflammation in EAE rodent models. AxCaliber showed axon diameter increases in mild relapsing remitting EAE group after R-ALA treatment. This might indicate a process of remyelination or other microstructural changes.

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