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Abstract #5422


Jing Xia1,2, Caiming Zhang1, Fan Wang2, Oualid M. Benkarim3, Gerard Sanroma 3, Gemma Piella3, Miguel A. Gonzalez Ballester3,4, Nadine Hahner5, Elisenda Eixarch5, Dinggang Shen2, and Gang Li2

1Department of Computer Science and Technology, Shandong University, Jinan, China, 2Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 3DTIC, Universitat Pompeu Fabra, Barcelona, Spain, 4ICREA, Pg. Lluis Companys 23, 08010, Barcelona, Spain, 5Fetal i+D Fetal Medicine Research Center, BCNatal, Hospital Clı́nic and Hospital Sant Joan de Déu, Barcelona, Spain

The available cortical parcellations created for adults are inapplicable for fetuses, due to dramatic differences in brain appearances and dynamic growth of fetal brains. Considering sulcal-gyral landmarks are not stably established in fetal brains, we propose to use the growth patterns of cortical properties to parcellate fetal cortical surfaces. Growth patterns, which reflect underlying changes of microstructures, enable an accurate definition of distinct regions in development and function, as microstructures determine the molecular organization and functional principles of the cortex. We apply the growth­-pattern-based method on 25 normal fetuses from 26 to 29 gestational weeks and generated biologically meaningful parcellations.

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