Abstract #5437

Changes in Resting-State Functional Brain Activity are Correlated with Waning Cognitive Functions in Pediatric HIV

Santosh K Yadav¹, Rakesh K Gupta², Sheema Hashem¹, Ajaz A Bhat¹, Ravindra K Garg³, Vimala Venkatesh⁴, Pradeep K Gupta², Alok K Singh³, Muhammad W Azeem⁵, Deepak Kaura⁶, and Mohammad Haris¹

¹Division of Translational Medicine, Sidra Medicine, Doha, Qatar, ²Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India, ³Department of Neurology, King George Medical University, Lucknow, India, ⁴Department of Microbiology, King George Medical University, Lucknow, India, ⁵Department of Psychiatry, Sidra Medicine, Doha, Qatar, ⁶Department of Diagnostic Imaging, Sidra Medicine, Doha, Qatar

We evaluated the functional brain changes in HIV-infected children by mapping the amplitude-of-low-frequency-fluctuations (ALFF) and functional connectivity (FC) using rs-fMRI. Association of these changes with cognitive measures was also explored. ALFF and FC were significantly altered in multiple brain regions involved in auditory, visual, language, motor and sensory activity. The waning cognitive functions in HIV-infected children were associated with the changes in ALFF and FC. These two imaging parameters in association with the cognitive evaluation may provide better understanding of the functional brain activity in HIV-infected children.

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