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Abstract #5447

StImulus Locked K-space shuffling (SILK) for ultra-high resolution fMRI

An Thanh Vu1,2, Alexander Beckett3,4, David Feinberg3,4, and Pratik Mukherjee1,2

1Radiology, San Francisco VA Health Care System, San Francisco, CA, United States, 2Center for Imaging of Neurodegenerative Diseases, University of California at San Francisco, San Francisco, CA, United States, 3Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA, United States, 4Advanced MRI Technologies, Sebastopol, CA, United States

Traditional EPI fMRI methods for acquiring sub-mm ultra-high resolution images require longer echo trains, resulting in SNR losses due to longer TEs, as well as, increased blurring in the phase encode (PE) direction, geometric distortion, and susceptibility dropout. StImulus Locked K-space shuffling or SILK-fMRI (e.g. in the context of 3D FLASH imaging) does not suffer from the above limitations but has never before been applied to fMRI. Here we demonstrate the feasibility of SILK fMRI vs. traditional EPI for 0.35 mm ultra-high resolution fMRI at 7T.

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