Abstract #5449

Optimising the detection of subcortical auditory function using fMRI

Rebecca Susan Dewey^1,2,3, Deborah A Hall^2,3, Hannah Guest⁴, Garreth Prendergast⁴, Christopher J Plack^4,5, and Susan T Francis¹

¹Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham, United Kingdom, ³Otology and Hearing Group, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁴Manchester Centre for Audiology and Deafness (ManCAD), University of Manchester, Manchester, United Kingdom, ⁵Department of Psychology, Lancaster University, Lancaster, United Kingdom

We explore the effects of EPI distortion correction and retrospective correction of cardiac and respiratory artefacts on fMRI data quality. Further, we assess the suitability of this data to provide robust detection of subcortical sound-evoked responses for inter-group and subgroup analyses. We report an optimum acquisition, pre-processing and analysis protocol for subcortical fMRI of the ascending auditory pathway.

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