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Abstract #5469

A comparison between amplitude of low frequency fluctuation calculation methods based on R2* signal and traditional T2*-weighted signal

Li-Xia Yuan1, Li-Sha Yuan1, Hong-Jian He1, Jian-Hui Zhong1, and Yu-Feng Zang2

1Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, 2Center for Cognition and Brain Disorders and the Affiliated Hospital,Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China

The amplitude of low frequency fluctuation (ALFF) is usually computed from T2*-weighted functional MRI (fMRI) signals, which is affected by R2* fluctuation, echo time, spin density, and mean R2*. To make ALFF more comparable and reliable between researches, we proposed a new method of ALFF calculation based on R2* (ALFF-R2*) in this work and further implemented for multi-echo fMRI. Statistical results from eyes-open and eyes-closed fMRI datasets show that ALFF-R2* detected an overall smaller significant regions than traditional ALFF in the paired T maps. The dice similarity coefficient between T maps from ALFF-R2* and traditional ALFF was 0.37. ALFF-R2* is potential to provide more specific results than traditional ALFF.

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