Abstract #5472

Multi-site reliability of Default Mode Network and Graph Theoretical Measures in Resting State fMRI

Sumra Bari¹, Pratik Kashyap¹, Kausar Abbas¹, Brenna C. McDonald², and Thomas M. Talavage¹

¹Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, ²Departments of Radiology and Imaging Sciences, Neurology, and Psychiatry, Indiana University School of Medicine, indianapolis, IN, United States

This study investigated the multi-site reliability of resting state fMRI (rs-fMRI) using Default Mode Network (DMN) connectivity and graph theory measures like mean shortest path distance, clustering coefficient, modularity, transitivity and global mean strength. Test-retest and between-site reliability for all metrics were calculated by variance component analysis using restricted maximum likelihood (REML) estimates. Test-retest reliability was found to be poor to fair and between-site reliability was consistently poor for all metrics.

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