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Abstract #5472

Multi-site reliability of Default Mode Network and Graph Theoretical Measures in Resting State fMRI

Sumra Bari1, Pratik Kashyap1, Kausar Abbas1, Brenna C. McDonald2, and Thomas M. Talavage1

1Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, 2Departments of Radiology and Imaging Sciences, Neurology, and Psychiatry, Indiana University School of Medicine, indianapolis, IN, United States

This study investigated the multi-site reliability of resting state fMRI (rs-fMRI) using Default Mode Network (DMN) connectivity and graph theory measures like mean shortest path distance, clustering coefficient, modularity, transitivity and global mean strength. Test-retest and between-site reliability for all metrics were calculated by variance component analysis using restricted maximum likelihood (REML) estimates. Test-retest reliability was found to be poor to fair and between-site reliability was consistently poor for all metrics.

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