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Abstract #5491

Myelin water fraction across the corpus callosum using multi-echo gradient echo at 7T - influence of model settings and flip angle

Kiran Thapaliya1, Viktor Vegh1, Steffen Bollmann1, and Markus Barth1

1Center for Advance Imaging, The University of Queensland, Brisbane, Australia

Proper quantitative assessment of myelin water fraction (MWF) using a multi-compartment model can be useful in improving our understanding of white matter diseases, however, MWF model estimates have been shown to be affected by model settings and also by T1 values of the myelin compartment. In this study, we investigated three common models using different number of parameters to assess MWF across the corpus callosum and the influence of acquisition flip angle at 7T.

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