Abstract #5494

A Feasibility Study of Quantifying Renal Microvascular Diameter and Density Using Vessel Size Imaging (VSI)

Chengyan Wang^1,2, Hanjing Kong², Fei Gao³, Li Jiang⁴, Jue Zhang^2,3, and Xiaoying Wang^2,5

¹Institute for Medical Imaging Technology, Shanghai Jiao Tong university, Shanghai, China, ²Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, ³College of Engineering, Peking University, Beijing, China, ⁴Philips Healthcare, Suzhou, China, ⁵Department of Radiology, Peking University First Hospital, Beijing, China

Information on renal microvascular architecture is still hardly accessible by clinical MRI techniques. This study explores the feasibility of using spin- and gradient-echo (SAGE) based dynamic susceptibility-contrast MRI for the quantification of renal microvascular diameter/density. Microvascular diameter (VSI) map, Q map and vessel density (D) map were calculated based on the differential dependence of R2/R2* relaxation rates on the capillary-sized vascular structures, which may provide a potentially important MR biomarker for the detection and staging of renal cell carcinoma

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