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Abstract #5509

Quantifying the Effect of Lipids’ Composition on Water Proton Relaxation

Oshrat Shtangel1 and Aviv Mezer1

1Edmond and Lily Safra Center for Brain Sciences, The Hebrew University,Edmond J. Safra Campus at Givat Ram, Jerusalem, Israel

It’s a major challenge to localize and quantify molecular content in the human brain for in-vivo MRI clinical use. Here, we formulated liposomes to model the environment of abundant lipids in the brain. To investigate the influence of those lipids on relaxation we estimated multiple quantitative MRI (qMRI) parameters. Moreover, we assess the relationship between the lipids’ qMRI parameters and the water fraction (WF). Our findings show that joining multiple qMRI parameters with the WF introduces a novel possibility to separate between different lipids' mixtures. Extending this approach can potentially be used to identify molecular signatures of human tissue in-vivo.

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