This work proposes a version of the two-compartment exchange model (2CXM) for dynamic contrast enhanced MRI that does not require an arterial input function (AIF). Instead, the proposed model uses the tracer-concentration from a reference region, with the assumption that the AIF is shared between the reference region and tissue of interest. The proposed model was evaluated in simulation and in-vivo where it had comparable performance to the conventional 2CXM with temporal sampling faster than 10 s. With slower temporal sampling, the reference region version had better accuracy and precision than the conventional 2CXM.
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