Abstract #5534

How people recover from extreme life stress: a longitudinal dynamic functional connectivity analysis

Jing Jiang¹, Kaiming Li², Xiaoqi Huang³, Su Lui³, Zhiyun Jia⁴, Qiang Yue³, Qiyong Gong³, and Qiyu Liu¹

¹Department of Radiology, Mianyang Central Hospital, Mianyang, China, ²Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China, ³Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ⁴Huaxi MR Research Center (HMRRC), Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China

Dynamic functional connectivity (dFC) has provided more information than commonly-used static FC analysis. With dFC, we investigated the variation characteristics of three affected resting state networks, i.e., DMN, CEN and SN, in trauma-exposed non-PTSD group using resting state fMRI scans within 25 days and 2 years after Wenchuan earthquake. Results revealed increased connectivity was mainly involved in intra-network FC of DMN and inter-network FC between SN and DMN/CEN. Decreased connectivity was mostly found in intra-network FC of CEN and inter-network FC between CEN and SN. This study may provide insights of how people recover from extreme life stress from a FC variation perspective.

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