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Abstract #5540

A correlation of resting state DfMRI signals reflects functional connectivity in awake mouse

Yoshifumi Abe1, Yuki Sakai2, Hiroaki Hamada3, Norio Takata1, Kenji Doya3, and Kenji Tanaka1

1Departemnt of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan, 2ATR Brain Information Communication Research Laboratory Group, Kyoto, Japan, 3Neural Computation Unit and Biological Physics Theory unit, Okinawa Insititute of Science and Technology, Okinawa, Japan

Diffusion fMRI (DfMRI) is an imaging method to investigate brain activity regardless of hemodynamic state. The previous study has proposed that resting state DfMRI (rsDfMRI) is suitable to investigate a magnitude of basal activity. In this study, we examined our hypothesis that this rsDfMRI have a potential of detecting functional connectivity (FC). FC patterns were compared between rsDfMRI and BOLD-rsfMRI in awake mice. A strong correlation of the pattern between rsDfMRI and BOLD-rsfMRI indicated that rsDfMRI is possible to conduct FC analysis. Therefore, we propose that rsDfMRI is a powerful tool to detect brain network as well as brain activity.

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