Abstract #5542

Functional Connectivity-Based Classification of Gulf War Illness Patients vs Control Veterans

Unal "Zak" Sakoglu¹, Mounika Galla¹, Bruce Crosson^2,3, Robert Haley⁴, and Kaundinya Gopinath⁵

¹Computer Engineering, University of Houston - Clear Lake, Houston, TX, United States, ²VA RR&D Center of Excellence, Atlanta VAMC, Decatur, GA, United States, ³Neurology, Emory University, Atlanta, GA, United States, ⁴Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, ⁵Radiology, Emory University, Atlanta, GA, United States

Around 200,000 veterans suffer from Gulf War Illness (GWI). GWI is characterized by multiple deficits in cognitive, emotion, somatosensory and pain domains. In this study we studied 23 GWI patients and 30 age-matched controls with resting state fMRI in order to classify patients versus controls using functional connectivity among brain networks. Results show that different brain networks have discriminating power, signaling widespread impairments in functional connectivity of visual, semantic, multi-sensory, and sensory-motor processing networks in GWI consistent with multi-symptom nature of the illness.

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