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Abstract #5545

Altered Variability in Functional Connectivity of the Anterior Cingulate Cortex in Patients with Treatment-resistant and Non-treatment-resistant Depression

Bochao Cheng1,2, Gang Ning1, and Qiyong Gong2

1Radiology, West China Second University Hospital of Sichuan University, Chengdu, China, 2Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, China

Although substantial efforts have been made to elucidate the neuronal basis of both Treatment-resistant depression (TRD) and non-TRD (nTRD), the results are inconsistant. We apply the resting-state dynamic functional connectivity (D-RSFC) to explore the divergence of neuronal basis of both depression subtypes. Our results demonstrated that the prefrontal-limbic circuit is the most stable dysfunctional brain network in depression. The D-RSFC method could reveal the altered dynamic functional connectivity in both MDD subtypes and the divergence of brain networks between TRD and nTRD. Additionally, we speculate that the caudate-ACC circuit might be the biomarker for evaluating treatment response in TRD.

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