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Abstract #5547

Resting Functional Connectivity Across a Language Network Not Related to Task Based Language Laterality Index

Akhila Ashokan1 and Victoria L Morgan2,3

1Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States, 2Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Quantification of language dominance via a laterality index is used to assess the risk of language impairment prior to temporal lobe resection, most commonly in temporal lobe epilepsy. While task based functional MRI has become a useful non-invasive method for this measure, its reliability and accuracy can be reduced by poor task performance. In this work, resting fMRI connectivity in a language based network was investigated as an easier and more robust alternative to task based methods. However, results showed poor associations between the resting connectivity and the task based laterality.

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