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Abstract #5554


Sirio Cocozza1, Giuseppe Pontillo1, Mario Quarantelli2, Francesco SaccĂ 3, Eleonora Riccio3, Teresa Costabile3, Gaia Olivo4, Vincenzo Brescia Morra3, Antonio Pisani3, Enrico Tedeschi1, and Arturo Brunetti1

1Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy, 2Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy, 3University of Naples "Federico II", Naples, Italy, 4Department of Neuroscience, Uppsala University, Uppsala, Sweden

We performed a Resting-State fMRI study to evaluate the integrity of the Default Mode Network (DMN) in Fabry Disease (FD), a condition in which neuropsychological symptoms are common and alterations of the functional connectivity (FC) have been recently reported. Compared to healthy controls FD patients showed clusters of increased FC involving different DMN hubs as well as the middle temporal gyri and the right cerebellum, with a significant correlation with the Corsi span test results (P=0.0001). Our results confirm the current view of a cerebral involvement in FD patients related to significant and diffuse functional changes.

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