Abstract #5554

DEFAULT MODE NETWORK MODIFICATIONS IN FABRY DISEASE

Sirio Cocozza¹, Giuseppe Pontillo¹, Mario Quarantelli², Francesco Saccà³, Eleonora Riccio³, Teresa Costabile³, Gaia Olivo⁴, Vincenzo Brescia Morra³, Antonio Pisani³, Enrico Tedeschi¹, and Arturo Brunetti¹

¹Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy, ²Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy, ³University of Naples "Federico II", Naples, Italy, ⁴Department of Neuroscience, Uppsala University, Uppsala, Sweden

We performed a Resting-State fMRI study to evaluate the integrity of the Default Mode Network (DMN) in Fabry Disease (FD), a condition in which neuropsychological symptoms are common and alterations of the functional connectivity (FC) have been recently reported. Compared to healthy controls FD patients showed clusters of increased FC involving different DMN hubs as well as the middle temporal gyri and the right cerebellum, with a significant correlation with the Corsi span test results (P=0.0001). Our results confirm the current view of a cerebral involvement in FD patients related to significant and diffuse functional changes.

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