We performed a Resting-State fMRI study to evaluate the integrity of the Default Mode Network (DMN) in Fabry Disease (FD), a condition in which neuropsychological symptoms are common and alterations of the functional connectivity (FC) have been recently reported. Compared to healthy controls FD patients showed clusters of increased FC involving different DMN hubs as well as the middle temporal gyri and the right cerebellum, with a significant correlation with the Corsi span test results (P=0.0001). Our results confirm the current view of a cerebral involvement in FD patients related to significant and diffuse functional changes.
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