Abstract #5563

Altered functional connectivity between cerebral and cerebellar resting-state networks in autism spectrum disorder

Yan Wang¹, Wenjing Zhang¹, Zheng Wang^2,3,4, Jieke Liu¹, John A. Sweeney^1,5, Stormi P. White⁶, Su Lui¹, and Matthew W. Mosconi^2,3,4

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ²Schiefelbusch Institute for Life Span Studies, University of Kansas, Lawrence, KS, United States, ³Clinical Child Psychology Program, University of Kansas, Lawrence, KS, United States, ⁴Kansas Center for Autism Research and Training (K-CART), University of Kansas, Lawrence, KS, United States, ⁵Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, United States, ⁶Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, TX, United States

By examining the correlation between motor data and brain resting-state functional imaging and identifying the functional connectivity alteration in ASD using a seed-driven approach, individuals with ASD demonstrate altered pattern of motor activation and diffusely decreased FC within frontal-subcortical-cerebellar circuit and within cerebellar network, which may represent the underlying neurobiological mechanisms of motor dysfunction and further delayed acquisition of gestures important for socialization and communication.

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