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Abstract #5563

Altered functional connectivity between cerebral and cerebellar resting-state networks in autism spectrum disorder

Yan Wang1, Wenjing Zhang1, Zheng Wang2,3,4, Jieke Liu1, John A. Sweeney1,5, Stormi P. White6, Su Lui1, and Matthew W. Mosconi2,3,4

1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Schiefelbusch Institute for Life Span Studies, University of Kansas, Lawrence, KS, United States, 3Clinical Child Psychology Program, University of Kansas, Lawrence, KS, United States, 4Kansas Center for Autism Research and Training (K-CART), University of Kansas, Lawrence, KS, United States, 5Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, United States, 6Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, TX, United States

By examining the correlation between motor data and brain resting-state functional imaging and identifying the functional connectivity alteration in ASD using a seed-driven approach, individuals with ASD demonstrate altered pattern of motor activation and diffusely decreased FC within frontal-subcortical-cerebellar circuit and within cerebellar network, which may represent the underlying neurobiological mechanisms of motor dysfunction and further delayed acquisition of gestures important for socialization and communication.

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