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Abstract #5566

fMRI-measured brain responses to smoking-related images before and after smoking cessation treatment by varenicline

Peng Peng1, Li Chunlin2, Jing Bin2, Chu Shuilian3, and Jiang Tao1

1Radiology, Beijing Chao-yang Hospital, Beijing, China, 2School of Biomedical Engineering, Capital Medical University, Beijing, China, 3Clinical Research Center, Beijing Chao-yang Hospital, Beijing, China

This study investigated the activation of brain regions to visual smoking cues in smokers before and after cessation treatment using an event-related design fMRI. The result demonstrated that smokers will have good tolerance to smoking-related stimuli after using varenicline. This may explain why the curative effect of varenicline is better than NRT which has been related to an increased the brain response. The results provide further evidence for medication choice of clinicians for smoking cessation.

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